Margarita Musto (born 16 November 1955) is a Uruguayan actress, theater director, translator, teacher, and general and artistic director of the Comedia Nacional. She graduated in 1982 from the Margarita Xirgu Multidisciplinary School of Dramatic Art (EMAD). In 1993 she played the leading role in La historia casi verdadera de Pepita la Pistolera, for which she received awards at the Guadalajara International Film Festival and the 12th Cinematographic Festival of Uruguay.