Known for Acting

Sirena grew up around the U.S. and abroad her mother, Margaret Irwin-Brandon, is a harpsichordist and conductor of a Baroque Orchestra, and her father, John Irwin, was a physicist (with a significant stint as a dropped out hippie)-landed ultimately at Sanford University. After time spent at Northfield Mt. Hermon boarding school where she fell in love with theater, she attended San Francisco State University and graduated with degrees in Theater and International Relations. After a successful stint in a popular San Francisco sketch comedy group, she landed in Los Angeles where her knack for voices and accents were quickly put to use in the world of animation. This ultimately brought her to her successful career as a voice director in animation (thanks to her mentor Andrea Romano!) garnering her an Emmy nomination in 2021.
2004
as Reporter / Driver / Ice Cream Lady (voice)
2015
as Computer Voice / Shocked Mob Member (voice)
2013
as Additional Voices (voice)
2024
as Lady Upturn / Nurse Helga / Mo / Teen Girls (voice)
2015
as Queen Atlanna (voice)
2017
as Harleen Quinzel (voice)
2013
as Alura (voice)
2016
as Miranda Moore (voice)
2002
as Beverly
2001
as Gabby
2016
as Fancy Lady Fish / Kid Fish (voice)
2007
as The Photographer
2019
as SpongeBob’s Mom / Gawky Female / The Kid / Office Worker
2008
2014
as Additional Voice
2011
as Margret SquarePants
2006
as Mrs. Palmer (voice)
2012
as Alisa
2025
as Pffht / Various Incidental Characters (voice)
2003
as Woman Fish